Article

Transcriptomic signatures associated with mania-to-depression and depression-to-mania transitions in bipolar disorder: a case report using induced microglia-like (iMG) cells

2026-07-15

Abstract excerpt

<h4>Introduction</h4> Bipolar disorder (BD) is characterized by recurring episodes of mania and depression. Despite extensive research, the pathophysiology underlying these mood swings remains elusive. Emerging evidence indicates a potential role for neuroinflammation and microglial activation in the pathophysiology of BD. <h4>Methods</h4> We employed a reverse-translational approach to generate directly induced...

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Literature Corpus work: 3f16d149-28d2-55ea-bbbd-688d1fa0eb1f
DOI: 10.64898/2026.07.12.735946

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