Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Autophagy inhibitors increase the susceptibility of KRAS-mutant human colorectal cancer cells to a combined treatment of 2-deoxy-D-glucose and lovastatin.

Acta pharmacologica Sinica - 1 Nov 2021

Huang Xiao-Ming, Huang Jia-Jun, Du Jing-Jing, Zhang Na, Long Ze, Yang You, Zhong Fang-Fang, Zheng Bo-Wen, Shen Yun-Fu, Huang Zhe, Qin Xiang, Chen Jun-He, Lin Qian-Yu, Lin Wan-Jun, Ma Wen-Zhe

Abstract excerpt

RAS-driven colorectal cancer relies on glucose metabolism to support uncontrolled growth. However, monotherapy with glycolysis inhibitors like 2-deoxy-D-glucose causes limited effectiveness. Recent studies suggest that anti-tumor effects of glycolysis inhibition could be improved by combination treatment with inhibitors of oxidative phosphorylation. In this study we investigated the effect of a combination of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimetabolites
Share to Autophagy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chloroquine

Share to Deoxyglucose

Share to HCT116 Cells

Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

Share to Lovastatin

Share to Xenograft Model Antitumor Assays

Source

Open in PubMed Open full text

Identifiers

PMID: 33608672
DOI: 10.1038/s41401-021-00612-9
PMCID: PMC8564510

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Autophagy inhibitors increase the susceptibility of KRAS-mutant human colorectal cancer cells to a combined treatment of 2-deoxy-D-glucose and lovastatin.PMID 33608672Read ↗

Vitamin C activates pyruvate dehydrogenase (PDH) targeting the mitochondrial tricarboxylic acid (TCA) cycle in hypoxic KRAS mutant colon cancer.Semantic proximity Read ↗

Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer.Semantic proximity Read ↗

Targeting metabolic reprogramming in KRAS-driven cancers.Semantic proximity Read ↗

Glucose Restriction Combined with Autophagy Inhibition and Chemotherapy in HCT 116 Spheroids Decreases Cell Clonogenicity and Viability Regulated by Tumor Suppressor GenesSemantic proximity Read ↗

Vitamin C selectively kills <i>KRAS</i> and <i>BRAF</i> mutant colorectal cancer cells by targeting GAPDHSemantic proximity Read ↗

Colorectal cancer cells utilize autophagy to maintain mitochondrial metabolism for cell proliferation under nutrient stressSemantic proximity Read ↗

Rewiring glucose metabolism improves 5-FU efficacy in p53-deficient/KRASG12D glycolytic colorectal tumorsSemantic proximity Read ↗

Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells.Semantic proximity Read ↗

Glycolysis inhibition sensitizes non-small cell lung cancer with T790M mutation to irreversible EGFR inhibitors via translational suppression of Mcl-1 by AMPK activation.Semantic proximity Read ↗

Modulation of energy metabolism to overcome drug resistance in chronic myeloid leukemia cells through induction of autophagySemantic proximity Read ↗

SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations and Xenograft Tumor Progression in Mice via Intracellular Synthesis of Aspartate.Semantic proximity Read ↗

The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.