Article
Phenotypic switch of smooth muscle cells in paediatric chronic intestinal pseudo-obstruction syndrome.
Journal of cellular and molecular medicine - 1 Apr 2021
Martire Delphine, Garnier Sarah, Sagnol Sébastien, Bourret Annick, Marchal Stéphane, Chauvet Norbert, Guérin Amandine, Forgues Dominique, Berrebi Dominique, Chardot Christophe, Bellaiche Marc, Rendu John, Kalfa Nicolas, Faure Sandrine, de Santa Barbara Pascal
Abstract excerpt
Smooth Muscle Cells (SMC) are unique amongst all muscle cells in their capacity to modulate their phenotype. Indeed, SMCs do not terminally differentiate but instead harbour a remarkable capacity to dedifferentiate, switching between a quiescent contractile state and a highly proliferative and migratory phenotype, a quality often associated to SMC dysfunction. However, phenotypic plasticity remains poorly...
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