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Article

Phenotypic switching of gastrointestinal smooth muscle cells and the regulatory role of macrophages: a literature review.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 19 Sept 2026

Fan Jinfei, Jiang Yue, Luan Xinchi, Wang Xuezhe, Wang Xin, Zhang Xiaolei, Tian Jingwen, Xin Xiaofei, Qiu Wensheng, Qi Weiwei

Abstract excerpt

BACKGROUND: Gastrointestinal motility disorders are closely associated with dysfunction of smooth muscle cells (SMCs), and phenotypic switching of SMCs serves as a critical pathological basis for this process. Under a chronic inflammatory microenvironment, SMCs can transform into a synthetic phenotype and contribute to complications such as intestinal fibrosis. Macrophages, as the predominant immune cell...

Read the complete abstract on PubMed

Topics

Humans
Macrophages
Animals
Myocytes, Smooth Muscle
Phenotype
Gastrointestinal Tract

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Inflammatory Bowel Diseases

Source

Identifiers

PMID: 42762326
DOI: 10.1007/s00011-026-02360-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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