Article
Effector and stem-like memory cell fates are imprinted in distinct lymph node niches directed by CXCR3 ligands.
Nature immunology - 1 Apr 2021
Duckworth Brigette C, Lafouresse Fanny, Wimmer Verena C, Broomfield Benjamin J, Dalit Lennard, Alexandre Yannick O, Sheikh Amania A, Qin Raymond Z, Alvarado Carolina, Mielke Lisa A, Pellegrini Marc, Mueller Scott N, Boudier Thomas, Rogers Kelly L, Groom Joanna R
Abstract excerpt
T cells dynamically interact with multiple, distinct cellular subsets to determine effector and memory differentiation. Here, we developed a platform to quantify cell location in three dimensions to determine the spatial requirements that direct T cell fate. After viral infection, we demonstrated that CD8+ effector T cell differentiation is associated with positioning at the lymph node periphery. This was...
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