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Article

CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver.

Journal of hepatology - 1 Nov 2012

Oo Ye Htun, Banz Vanessa, Kavanagh Dean, Liaskou Evaggelia, Withers David R, Humphreys Elizabeth, Reynolds Gary M, Lee-Turner Laura, Kalia Neena, Hubscher Stefan G, Klenerman Paul, Eksteen Bertus, Adams David H

Abstract excerpt

BACKGROUND & AIMS: IL-17 secreting CD4 (Th17) and CD8 (Tc17) T cells have been implicated in immune-mediated liver diseases, but the molecular basis for their recruitment and positioning within the liver is unknown. METHODS: The phenotype and migratory behaviour of human liver-derived Th17 and Tc17 cells were investigated by flow cytometry and chemotaxis and flow-based adhesion assays. The recruitment of murine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22796894
DOI: 10.1016/j.jhep.2012.07.008
PMCID: PMC3994510

Genes

CXCR3
CCR6
CCL20
CXCR6
RORC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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