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Selective extraction of low-abundance BRAF V600E mutation from plasma, urine, and sputum using ion-tagged oligonucleotides and magnetic ionic liquids.

Analytical and bioanalytical chemistry - 1 Jan 2022

Emaus Miranda N, Anderson Jared L

Abstract excerpt

Sequence-specific DNA extractions have the potential to improve the detection of low-abundance mutations from complex matrices, making them ideal for circulating tumor DNA analysis during the early stages of cancer. Ion-tagged oligonucleotides (ITOs) are oligonucleotides modified with an allylimidazolium salt via thiolene click chemistry. The allylimidazolium-based tag allows the ITO-DNA duplex to be selectively...

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PMID: 33644840
DOI: 10.1007/s00216-021-03216-8

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