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Article

Nutritive Manganese and Zinc Overdosing in Aging C. elegans Result in a Metallothionein-Mediated Alteration in Metal Homeostasis.

Molecular nutrition & food research - 1 Apr 2021

Baesler Jessica, Michaelis Vivien, Stiboller Michael, Haase Hajo, Aschner Michael, Schwerdtle Tanja, Sturzenbaum Stephen R, Bornhorst Julia

Abstract excerpt

SCOPE: Manganese (Mn) and zinc (Zn) are not only essential trace elements, but also potential exogenous risk factors for various diseases. Since the disturbed homeostasis of single metals can result in detrimental health effects, concerns have emerged regarding the consequences of excessive exposures to multiple metals, either via nutritional supplementation or parenteral nutrition. This study focuses on...

Topics

Aging
Animals
Animals, Genetically Modified
Biological Availability
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Dopaminergic Neurons
Drug Overdose
Homeostasis
Manganese

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Metallothionein

Mutation

Toxicity Tests, Chronic

Ubiquitin-Protein Ligases

Zinc

Source

Open in PubMed Open full text

Identifiers

PMID: 33641237
DOI: 10.1002/mnfr.202001176
PMCID: PMC8224813

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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