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Article

Hexavalent chromium neurotoxicity in Caenorhabditis elegans targeted GABAergic, cholinergic, and dopaminergic neurons, and contributed to an aged phenotype.

Neurotoxicology - 1 Dec 2025

Vielee Samuel T, Chen Pan, Deza-Ponzio Romina, Meaza Idoia, Sammi Shreesh Raj, Aschner Michael, Wise John P

Abstract excerpt

Hexavalent chromium [Cr(VI)] is a ubiquitous environmental pollutant and potent toxicant. Cr(VI) exposure impacts millions of people around the world, primarily through inhalation or ingestion. Such exposures are best known for contributing to cancers of the lung, sinus, and nasal passage, damage to kidneys and liver, and contact dermatitis. Growing evidence indicates exposure contributes to neurological...

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Identifiers

PMID: 40976548
DOI: 10.1016/j.neuro.2025.103325
PMCID: PMC13097108

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