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Article

Genetically predicted circulating levels of copper and zinc are associated with osteoarthritis but not with rheumatoid arthritis.

Osteoarthritis and cartilage - 1 Jul 2021

Zhou J, Liu C, Sun Y, Francis M, Ryu M S, Grider A, Ye K

Abstract excerpt

OBJECTIVE: Osteoarthritis (OA) and rheumatoid arthritis (RA) are both debilitating diseases that cause significant morbidity and disability globally. This study aims to investigate the causal effects of varying blood levels of five minerals -- iron, zinc, copper, calcium, and magnesium, on OA and RA. DESIGN: We performed two-sample Mendelian randomization (MR) analyses to assess the associations of five...

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Identifiers

PMID: 33640581
DOI: 10.1016/j.joca.2021.02.564

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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