Article
Design of immunogens to elicit broadly neutralizing antibodies against HIV targeting the CD4 binding site.
Proceedings of the National Academy of Sciences of the United States of America - 2 Mar 2021
Conti Simone, Kaczorowski Kevin J, Song Ge, Porter Katelyn, Andrabi Raiees, Burton Dennis R, Chakraborty Arup K, Karplus Martin
Abstract excerpt
A vaccine which is effective against the HIV virus is considered to be the best solution to the ongoing global HIV/AIDS epidemic. In the past thirty years, numerous attempts to develop an effective vaccine have been made with little or no success, due, in large part, to the high mutability of the virus. More recent studies showed that a vaccine able to elicit broadly neutralizing antibodies (bnAbs), that is,...
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