Article
A critical question for HIV vaccine development: which antibodies to induce?
Science (New York, N.Y.) - 11 Jul 2014
Zolla-Pazner Susan
Abstract excerpt
A vaccine against HIV-1 must prevent infection against genetically diverse virus strains. Two approaches are currently being pursued to elicit antibody-mediated protection: vaccines that induce potent and broadly reactive neutralizing antibodies (bnAbs) or vaccines that induce "conventional antibodies," which are less potent and broadly neutralizing in comparison. Although bnAbs may provide the greatest level of...
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