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Article

Genetic and epigenetic evolution as a contributor to WT1-mutant leukemogenesis.

Blood - 20 Sept 2018

Pronier Elodie, Bowman Robert L, Ahn Jihae, Glass Jacob, Kandoth Cyriac, Merlinsky Tiffany R, Whitfield Justin T, Durham Benjamin H, Gruet Antoine, Hanasoge Somasundara Amritha Varshini, Rampal Raajit, Melnick Ari, Koche Richard P, Taylor Barry S, Levine Ross L

Abstract excerpt

Genetic studies have identified recurrent somatic mutations in acute myeloid leukemia (AML) patients, including in the Wilms' tumor 1 (WT1) gene. The molecular mechanisms by which WT1 mutations contribute to leukemogenesis have not yet been fully elucidated. We investigated the role of Wt1 gene dosage in steady-state and pathologic hematopoiesis. Wt1 heterozygous loss enhanced stem cell self-renewal in an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30064973
DOI: 10.1182/blood-2018-03-837468
PMCID: PMC6148447

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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