Article
Replication of progressive supranuclear palsy genome-wide association study identifies SLCO1A2 and DUSP10 as new susceptibility loci.
Molecular neurodegeneration - 9 Jul 2018
Sanchez-Contreras Monica Y, Kouri Naomi, Cook Casey N, Serie Daniel J, Heckman Michael G, Finch NiCole A, Caselli Richard J, Uitti Ryan J, Wszolek Zbigniew K, Graff-Radford Neill, Petrucelli Leonard, Wang Li-San, Schellenberg Gerard D, Dickson Dennis W, Rademakers Rosa, Ross Owen A
Abstract excerpt
BACKGROUND: Progressive supranuclear palsy (PSP) is a parkinsonian neurodegenerative tauopathy affecting brain regions involved in motor function, including the basal ganglia, diencephalon and brainstem. While PSP is largely considered to be a sporadic disorder, cases with suspected familial inheritance have been identified and the common MAPT H1haplotype is a major genetic risk factor. Due to the relatively low...
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