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Chicken cGAS Senses Fowlpox Virus Infection and Regulates Macrophage Effector Functions

1 Feb 2021

Abstract excerpt

The anti-viral immune response is dependent on the ability of infected cells to sense foreign nucleic acids. In multiple species, the pattern recognition receptor (PRR) cyclic GMP-AMP synthase (cGAS) senses viral DNA as an essential component of the innate response. cGAS initiates a range of signaling outputs that are dependent on generation of the second messenger cGAMP that binds to the adaptor protein...

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PMID: 33633733
DOI: 10.3389/fimmu.2020.613079

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