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Article

Whole-genome sequencing reveals KRTAP1-1 as a novel genetic variant associated with antidepressant treatment outcomes.

Scientific reports - 25 Feb 2021

Park Jong-Ho, Lim Shinn-Won, Myung Woojae, Park Inho, Jang Hyeok-Jae, Kim Seonwoo, Lee Min-Soo, Chang Hun Soo, Yum DongHo, Suh Yeon-Lim, Kim Jong-Won, Kim Doh Kwan

Abstract excerpt

Achieving remission following initial antidepressant therapy in patients with major depressive disorder (MDD) is an important clinical result. Making predictions based on genetic markers holds promise for improving the remission rate. However, genetic variants found in previous genetic studies do not provide robust evidence to aid pharmacogenetic decision-making in clinical settings. Thus, the objective of this...

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Identifiers

PMID: 33633223
DOI: 10.1038/s41598-021-83887-6
PMCID: PMC7907209

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