Article
Whole-exome sequencing identifies a polymorphism in the BMP5 gene associated with SSRI treatment response in major depression.
Journal of psychopharmacology (Oxford, England) - 1 Oct 2013
Tammiste Anu, Jiang Tao, Fischer Krista, Mägi Reedik, Krjutškov Kaarel, Pettai Kristi, Esko Tõnu, Li Yingrui, Tansey Katherine E, Carroll Liam S, Uher Rudolf, McGuffin Peter, Võsa Urmo, Tšernikova Natalia, Saria Alois, Ng Pauline C, Eller Triin, Vasar Veiko, Nutt David J, Maron Eduard, Wang Jun, Metspalu Andres
Abstract excerpt
Although antidepressants are widely used in the pharmacotherapy of major depressive disorder (MDD), their efficacy is still insufficient as approximately one-third of the patients do not fully recover even after several treatment trials. Inter-individual genetic differences are thought to contribute to the variability in antidepressant response; however, current findings from pharmacogenetic studies are uncertain...
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