Article
Sex-specific associations between AD genotype and the microbiome of human amyloid beta knock-in (hAβ-KI) mice.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jul 2024
Dunham Sage J B, Avelar-Barragan Julio, Rothman Jason A, Adams Eric D, Faraci Gina, Forner Stefania, Kawauchi Shimako, Tenner Andrea J, Green Kim N, LaFerla Frank M, MacGregor Grant R, Mapstone Mark, Whiteson Katrine L
Abstract excerpt
INTRODUCTION: Emerging evidence links changes in the gut microbiome to late-onset Alzheimer's disease (LOAD), necessitating examination of AD mouse models with consideration of the microbiome. METHODS: We used shotgun metagenomics and untargeted metabolomics to study the human amyloid beta knock-in (hAβ-KI) murine model for LOAD compared to both wild-type (WT) mice and a model for early-onset AD (3xTg-AD)....
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