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Alterations in the Kynurenine Pathway of Tryptophan Metabolism Are Associated With Depression in People Living With HIV

27 Feb 2021

Abstract excerpt

BACKGROUND: People living with HIV have increased risk of depression compared with uninfected controls. The determinants of this association are unclear. Alterations in kynurenine (Kyn) metabolism have been associated with depression in uninfected individuals, but whether they are involved in the development of depression in the context of HIV infection is unknown. METHODS: A total of 909 people living with HIV...

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PMID: 33633032
DOI: 10.1097/qai.0000000000002664

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