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Article

Sex-Specific Alterations of the Kynurenine Pathway in Association With Risk for and Remission of Depression in Adolescence

25 Mar 2025

Abstract excerpt

BACKGROUND: The imbalance between neurotoxic and neuroprotective metabolites of the kynurenine pathway has been implicated in the pathophysiology of major depressive disorder (MDD) in adulthood but has not been fully investigated among adolescents. In this study, we tested the association of kynurenine pathway metabolites with risk for and remission of adolescent depression and whether abnormalities in the...

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PMID: 40131256
DOI: 10.1016/j.biopsych.2024.11.020

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