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Associations between Kynurenine pathway metabolites and cognitive dysfunction in major depressive disorder

18 Aug 2025

Abstract excerpt

This research sought to investigate the relationship between cognitive impairment and kynurenine pathway metabolites in individuals diagnosed with major depressive disorder (MDD). A total of 67 patients diagnosed with MDD and 61 healthy controls (HC) were enrolled in this study. Cognitive function was assessed utilizing the MATRICS Consensus Cognitive Battery. Plasma levels of tryptophan (TRP), kynurenine (KYN),...

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PMID: 40824856
DOI: 10.1371/journal.pone.0328886

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