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Article

Schistosoma japonicum Infection in Treg-Specific USP21 Knockout Mice.

Journal of immunology research - 1 Jan 2021

Zhang Youxiang, Xiong De-Hui, Li Yangyang, Xu Guina, Zhang Baoxin, Liu Yang, Zhang Shan, Huang Qing, Chen Simin, Zeng Fansheng, Guo Jingyi, Li Bin, Qin Zhiqiang, Zhang Zuping

Abstract excerpt

The E3 deubiquitinating enzyme ubiquitin-specific proteolytic enzyme 21 (USP21) plays vital roles in physiological activities and is required for Treg-cell-mediated immune tolerance. Using a murine model infected with Schistosoma japonicum, we observed that there were more cercariae developed into adults and more eggs deposited in the livers of the USP21fl/flFOXP3Cre (KO) mice. However, immunohistochemistry...

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PMID: 33628844
DOI: 10.1155/2021/6613162
PMCID: PMC7886505

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