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Echinococcus granulosus ubiquitin-conjugating enzymes (E2D2 and E2N) promote the formation of liver fibrosis in TGFβ1-induced LX-2 cells.

Parasites & vectors - 20 Apr 2024

Du Xiaodi, Hua Ruiqi, He Xue, Hou Wei, Li Shengqiong, Yang Aiguo, Yang Guangyou

Abstract excerpt

BACKGROUND: Cystic echinococcosis (CE) is a widespread zoonosis caused by the infection with Echinococcus granulosus sensu lato (E. granulosus s.l.). CE cysts mainly develop in the liver of intermediate hosts, characterized by the fibrotic tissue that separates host organ from parasite. However, precise mechanism underlying the formation of fibrotic tissue in CE remains unclear. METHODS: To investigate the...

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PMID: 38643149
DOI: 10.1186/s13071-024-06222-8
PMCID: PMC11031992

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