Article

SOX9 plays an essential role in myofibroblast driven hepatic granuloma integrity and parenchymal repair during schistosomiasis-induced liver damage

2025-01-25

Abstract excerpt

Schistosomiasis is a neglected, and potentially lethal, parasitic disease that affects hundreds of millions of people worldwide. As part of the schistosome lifecycle, parasite eggs accumulate within the liver where they evoke intense granulomatous pathology, typified by a dense extracellular matrix (ECM) barrier, which serves to contain toxic egg secretions. In severe cases, this progressive and irreversible egg-e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cfd36c43-fc83-52bb-849e-9dc64306e033
DOI: 10.1101/2025.01.23.634445

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SOX9 plays an essential role in myofibroblast driven hepatic granuloma integrity and parenchymal repair during schistosomiasis-induced liver damageDOI 10.1101/2025.01.23.634445Read

SOX9: a key transcriptional regulator in organ fibrosisSemantic proximity Read

Programmed genome editing of the omega-1 ribonuclease 1 of the blood fluke, Schistosoma mansoniSemantic proximity Read

The transcriptome of Schistosoma mansoni developing eggs reveals key mediators in pathogenesis and life cycle propagationSemantic proximity Read

Single-cell and spatial transcriptomics unveils key regulators governing cell differentiation for Schistosoma japonicum sexual developmentSemantic proximity Read

SOX9 regulated matrix proteins are increased in patients serum and correlate with severity of liver fibrosisSemantic proximity Read

Induction of hepatic fibrosis in mice with schistosomiasis by extracellular microRNA-30 derived from Schistosoma japonicum eggsSemantic proximity Read

Omega-1 knockdown in Schistosoma mansoni eggs by lentivirus transduction reduces granuloma size in vivoSemantic proximity Read

Transcriptome of the parasitic flatworm Schistosoma mansoni during intra-mammalian developmentSemantic proximity Read

The Transcriptome of Schistosoma mansoni Developing Eggs Reveals Key Mediators in Pathogenesis and Life Cycle PropagationSemantic proximity Read

Dynamics of collagen, MMP and TIMP gene expression during the granulomatous, fibrotic process induced bySchistosoma mansonieggsSemantic proximity Read

JQ-1 ameliorates schistosomiasis liver fibrosis by suppressing JAK2 and STAT3 activationSemantic proximity Read

Artemisitene protected against murine schistosomiasis japonica through anti-parasite activity and immune regulationSemantic proximity Read