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Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane.

Cell death & disease - 24 Feb 2021

Phatak Vinaya, von Grabowiecki Yannick, Janus Justyna, Officer Leah, Behan Caron, Aschauer Lydia, Pinon Lucia, Mackay Hannah, Zanivan Sara, Norman Jim C, Kelly Michael, Le Quesne John, Muller Patricia A J

Abstract excerpt

TP53 is the most frequently mutated gene in cancers. Mutations lead to loss of p53 expression or expression of a mutant protein. Mutant p53 proteins commonly lose wild-type function, but can also acquire novel functions in promoting metastasis and chemoresistance. Previously, we uncovered a role for Rab-coupling protein (RCP) in mutant p53-dependent invasion. RCP promotes endosomal recycling and signalling of...

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Identifiers

PMID: 33627632
DOI: 10.1038/s41419-021-03497-y
PMCID: PMC7904762

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