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Article

The small GTPases Rab5 and RalA regulate intracellular traffic of P-glycoprotein.

Biochimica et biophysica acta - 1 Jul 2007

Fu Dong, van Dam Ellen M, Brymora Adam, Duggin Iain G, Robinson Phillip J, Roufogalis Basil D

Abstract excerpt

P-glycoprotein (P-gp) is a plasma membrane glycoprotein that can cause multidrug resistance (MDR) of cancer cells by acting as an ATP-dependent drug efflux pump. The regulatory effects of the small GTPases Rab5 and RalA on the intracellular trafficking of P-gp were investigated in HeLa cells. As...

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Source

Identifiers

PMID: 17524504
DOI: 10.1016/j.bbamcr.2007.03.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17524504-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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