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Article

Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion.

Cell reports - 7 Jul 2020

Zhang Shaosen, Wang Caihong, Ma Boyuan, Xu Min, Xu Siran, Liu Jie, Tian Yang, Fu Yan, Luo Yongzhang

Abstract excerpt

Mutant p53 (mutp53) loses its tumor suppressor properties but gains oncogenic functions of driving malignancy. However, it remains largely unknown how mutp53 drives cancer metastasis. Here, we show that wild-type p53 (WTp53) suppresses the secretion of heat shock protein 90-alpha (Hsp90α), whereas mutp53 enhances Hsp90α vesicular trafficking and exosome-mediated secretion. Long-term delivery of an antibody that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32640214
DOI: 10.1016/j.celrep.2020.107879

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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