Article
Polymorphisms in oxidative stress-related genes are associated with nasopharyngeal carcinoma susceptibility.
Immunobiology - 1 Jan 2015
Ben Chaaben Arij, Mariaselvam Christina, Salah Sofiane, Busson Marc, Dulphy Nicolas, Douik Hayet, Ghanem Abderraouf, Boukaouci Wahid, Al Daccak Reem, Mamoghli Tesnim, Harzallah Latifa, Bouassida Jihene, Fortier Catherine, Gritli Said, Ben Hamida Jeannette, Charron Dominique, Krishnamoorthy Rajagopal, Guemira Fethi, Tamouza Ryad
Abstract excerpt
Nasopharyngeal carcinoma (NPC) is a complex multifactorial disorder involving both genetic and environmental factors. Polymorphisms of genes encoding nitric oxide synthase (NOS) and antioxidant glutathione-S transferases (GSTs) have been associated with various tumors. We examined the combined role of NOS3, NOS2 and GST polymorphisms in NPC risk in Tunisians. We found that NOS3−786C allele and −786 CC genotype,...
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