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Simulated microgravity accelerates aging in Saccharomyces cerevisiae.

Life sciences in space research - 1 Feb 2021

Fukuda Ana Paula Montanari, Camandona Vittoria de Lima, Francisco Kelliton José Mendonça, Rios-Anjos Rafaela Maria, Lucio do Lago Claudimir, Ferreira-Junior Jose Ribamar

Abstract excerpt

The human body experiences physiological changes under microgravity environment that phenocopy aging on Earth. These changes include early onset osteoporosis, skeletal muscle atrophy, cardiac dysfunction, and immunosenescence, and such adaptations to the space environment may pose some risk to crewed missions to Mars. To investigate the effect of microgravity on aging, many model organisms have been used such as...

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PMID: 33612178
DOI: 10.1016/j.lssr.2020.12.003

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