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KRAS G12C-mutated advanced non-small cell lung cancer: A real-world cohort from the German prospective, observational, nation-wide CRISP Registry (AIO-TRK-0315).

Lung cancer (Amsterdam, Netherlands) - 1 Apr 2021

Sebastian Martin, Eberhardt Wilfried E E, Hoffknecht Petra, Metzenmacher Martin, Wehler Thomas, Kokowski Konrad, Alt Jürgen, Schütte Wolfgang, Büttner Reinhard, Heukamp Lukas C, Stenzinger Albrecht, Jänicke Martina, Fleitz Annette, Zacharias Stefan, Dille Stephanie, Hipper Annette, Sandberg Marlen, Weichert Wilko, Groschek Matthias, von der Heyde Eyck, Rauh Jacqueline, Dechow Tobias, Thomas Michael, Griesinger Frank

Abstract excerpt

OBJECTIVES: After decades of unsuccessful efforts in inhibiting KRAS, promising clinical data targeting the mutation subtype G12C emerge. Since little is known about outcome with standard treatment of patients with G12C mutated non-small cell lung cancer (NSCLC), we analyzed a large, representative, real-world cohort from Germany. PATIENTS AND METHODS: A total of 1039 patients with advanced KRAS-mutant or...

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PMID: 33611226
DOI: 10.1016/j.lungcan.2021.02.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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