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Article

A retrospective observational study of the natural history of advanced non-small-cell lung cancer in patients with KRAS p.G12C mutated or wild-type disease.

Lung cancer (Amsterdam, Netherlands) - 1 Sept 2021

Spira Alexander I, Tu Huakang, Aggarwal Shivani, Hsu Hil, Carrigan Gillis, Wang Xuena, Ngarmchamnanrith Gataree, Chia Victoria, Gray Jhanelle E

Abstract excerpt

INTRODUCTION: The KRAS p.G12C mutation, prevalent in non-small-cell lung cancer (NSCLC), has only recently become a viable target. Here we present results of the largest retrospective observational study analyzing KRAS p.G12C in patients with advanced NSCLC. MATERIALS AND METHODS: Adults with advanced NSCLC (All Advanced NSCLC cohort) and subcohorts with different mutation profiles (KRAS p.G12C [G12C] and...

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PMID: 34293517
DOI: 10.1016/j.lungcan.2021.05.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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