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Article

Depression and multiple sclerosis: A bidirectional Mendelian randomisation study.

Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Oct 2021

Binzer Stefanie, Jiang Xia, Hillert Jan, Manouchehrinia Ali

Abstract excerpt

Depression is common in multiple sclerosis (MS); however, the underlying mechanism for the relationship remains unknown. In this study, we examined a putative causal relationship between depression and MS using a bidirectional Mendelian randomisation (MR) framework. Using the latest genome-wide association study data available, 168 non-major histocompatibility complex (MHC) independent variants associated with MS...

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Identifiers

PMID: 33605804
DOI: 10.1177/1352458521996601
PMCID: PMC8474318

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