Article
Risk SNP-induced lncRNA-SLCC1 drives colorectal cancer through activating glycolysis signaling.
Signal transduction and targeted therapy - 19 Feb 2021
Yan Tingting, Shen Chaoqin, Jiang Penglei, Yu Chenyang, Guo Fangfang, Tian Xianglong, Zhu Xiaoqiang, Lu Shiyuan, Han Bingshe, Zhong Ming, Chen Jinxian, Liu Qiang, Chen Yingxuan, Zhang Junfang, Hong Jie, Chen Haoyan, Fang Jing-Yuan
Abstract excerpt
Long non-coding RNAs (lncRNAs) play key roles in colorectal carcinogenesis. Here, we aimed to identify the risk SNP-induced lncRNAs and to investigate their roles in colorectal carcinogenesis. First, we identified rs6695584 as the causative SNP in 1q41 locus. The A>G mutation of rs6695584 created a protein-binding motif of BATF, altered the enhancer activity, and subsequently activated lncSLCC1 expression....
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