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Article

GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma

18 Feb 2021

Abstract excerpt

Abstract One of the greatest barriers to curative treatment of neuroblastoma is its frequent metastatic outgrowth prior to diagnosis, especially in cases driven by amplification of the MYCN oncogene. However, only a limited number of regulatory proteins that contribute to this complex MYCN-mediated process have been elucidated. Here we show that the growth arrest-specific 7 (GAS7) gene, located at chromosome band...

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PMID: 33602789
DOI: 10.1158/0008-5472.can-20-1890

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