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Focal DNA Copy Number Changes in Neuroblastoma Target MYCN Regulated Genes

4 Jan 2013

Abstract excerpt

Neuroblastoma is an embryonic tumor arising from immature sympathetic nervous system cells. Recurrent genomic alterations include MYCN and ALK amplification as well as recurrent patterns of gains and losses of whole or large partial chromosome segments. A recent whole genome sequencing effort yielded no frequently recurring mutations in genes other than those affecting ALK. However, the study further stresses the...

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PMID: 23308108
DOI: 10.1371/journal.pone.0052321

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