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Article

Clusterin, a Haploinsufficient Tumor Suppressor Gene in Neuroblastomas

29 Apr 2009

Abstract excerpt

BACKGROUND: Clusterin expression in various types of human cancers may be higher or lower than in normal tissue, and clusterin may promote or inhibit apoptosis, cell motility, and inflammation. We investigated the role of clusterin in tumor development in mouse models of neuroblastoma. METHODS: We assessed expression of microRNAs in the miR-17-92 cluster by real-time reverse transcription-polymerase chain...

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PMID: 19401549
DOI: 10.1093/jnci/djp063

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