Article
Infectious prions in pre-clinical deer and transmission of chronic wasting disease solely by environmental exposure.
PloS one - 16 Jun 2009
Mathiason Candace K, Hays Sheila A, Powers Jenny, Hayes-Klug Jeanette, Langenberg Julia, Dahmes Sallie J, Osborn David A, Miller Karl V, Warren Robert J, Mason Gary L, Hoover Edward A
Abstract excerpt
Key to understanding the epidemiology and pathogenesis of prion diseases, including chronic wasting disease (CWD) of cervids, is determining the mode of transmission from one individual to another. We have previously reported that saliva and blood from CWD-infected deer contain sufficient infectious prions to transmit disease upon passage into naïve deer. Here we again use bioassays in deer to show that blood and...
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