Targeting FLT-3 Mutations in Acute Myeloid Leukaemia: from Molecular Insights to Clinical Strategies.

Abstract excerpt

FMS-like tyrosine kinase 3 (FLT-3) mutations represent one of the most common genetic anomalies in acute myeloid leukaemia (AML), particularly in adults. The two most common types of mutations, internal tandem duplications (ITD) and tyrosine kinase domain (TKD) point mutations, facilitate uncontrolled cellular proliferation and unfavourable patient outcomes. These mutations are linked with a high relapse rate and...

Topics

• Humans
• fms-Like Tyrosine Kinase 3
• Leukemia, Myeloid, Acute
• Mutation
• Protein Kinase Inhibitors
• Molecular Targeted Therapy
• Aniline Compounds
• Pyrazines