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FLT3 Mutations in Acute Myeloid Leukemia: Key Concepts and Emerging Controversies

23 Dec 2020

Abstract excerpt

The FLT3 receptor is overexpressed on the majority of acute myeloid leukemia (AML) blasts. Mutations in FLT3 are the most common genetic alteration in AML, identified in approximately one third of newly diagnosed patients. FLT3 internal tandem duplication mutations (FLT3-ITD) are associated with increased relapse and inferior overall survival. Multiple small molecule inhibitors of FLT3 signaling have been...

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PMID: 33425766
DOI: 10.3389/fonc.2020.612880

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