Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular differences of angiogenic versus vessel co-opting colorectal cancer liver metastases at single-cell resolution

23 Jan 2023

Abstract excerpt

BACKGROUND: Colorectal cancer liver metastases (CRCLM) are associated with a poor prognosis, reflected by a five-year survival rate of 14%. Anti-angiogenic therapy through anti-VEGF antibody administration is one of the limited therapies available. However, only a subgroup of metastases uses sprouting angiogenesis to secure their nutrients and oxygen supply, while others rely on vessel co-option (VCO). The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiogenesis and VEGF in Cancer
Share to Cancer Cells and Metastasis
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36691028
DOI: 10.1186/s12943-023-01713-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular differences of angiogenic versus vessel co-opting colorectal cancer liver metastases at single-cell resolutionPMID 36691028Read ↗

Histopathological growth patterns determines the outcomes of colorectal cancer liver metastasis that have undergone liver resectionSemantic proximity Read ↗

Prognostic value and spatial transcriptomic landscape of histopathological growth patterns in synchronous colorectal liver metastases.Semantic proximity Read ↗

Molecular characterization of the histopathological growth patterns of colorectal cancer liver metastases by RNA sequencing of targeted samples at the tumor-liver interface.Semantic proximity Read ↗

Molecular characterization of the histopathological growth patterns of colorectal cancer liver metastases by RNA sequencing of targeted samples at the tumor-liver interfaceSemantic proximity Read ↗

Deciphering Colorectal Liver Metastasis Perfusion Heterogeneity: Identification of Distinct Vascular Phenotypes through High-Lateral-Resolution Photoacoustic Microscopy.Semantic proximity Read ↗

Single-cell and spatial transcriptomics define a C3-centred multicellular ecology in colorectal liver metastasisSemantic proximity Read ↗

Single-cell and spatial transcriptome analysis reveals the cellular heterogeneity of liver metastatic colorectal cancerSemantic proximity Read ↗

Transcriptomic characterization of the histopathological growth patterns in breast cancer liver metastasesSemantic proximity Read ↗

Angiogenesis–metabolism transcriptional relationship in HCC and iCCA liver cancer throughout tumor progression from single-cell RNA sequencingSemantic proximity Read ↗

Spatial Transcriptomics Reveals Stromal-Partitioned Growth in Primary Colorectal Cancer and Host-Permeated Architecture in Liver MetastasesSemantic proximity Read ↗

The landscape of cancer-associated fibroblasts in colorectal cancer liver metastasesSemantic proximity Read ↗

Spatial transcriptomic revealed intratumor heterogeneity and cancer stem cell enrichment in colorectal cancer metastasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.