Article
High prevalence of heteroresistance in Staphylococcus aureus is caused by a multitude of mutations in core genes.
PLoS biology - 1 Jan 2024
Heidarian Sheida, Guliaev Andrei, Nicoloff Hervé, Hjort Karin, Andersson Dan I
Abstract excerpt
Heteroresistance (HR) is an enigmatic phenotype where, in a main population of susceptible cells, small subpopulations of resistant cells exist. This is a cause for concern, as this small subpopulation is difficult to detect by standard antibiotic susceptibility tests, and upon antibiotic exposure the resistant subpopulation may increase in frequency and potentially lead to treatment complications or failure....
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