Article
Association of PON1, TNF-α and TGF-β gene polymorphisms with prognosis in oral and oropharyngeal squamous cell carcinoma.
Acta odontologica Scandinavica - 1 Jul 2021
Santana Ingrede Tatiane Serafim, Dos Santos José Nilson Andrade, de Almeida Vinicius Lima, Ferreira Waldhenice Nunes Silveira, Santos Edilmar Moura, de Almeida Freitas Roseana, Pinto Claudia Cristina Kaiser, de Carvalho Barreto Ikaro Daniel, de Matos Felipe Rodrigues
Abstract excerpt
OBJECTIVE: The oral and oropharyngeal squamous cell carcinoma (OOSCC) accounts for 90-95% of tumours in the oral cavity. Single nucleotide polymorphism (SNP) in the coding region of PON1, tumour necrosis factor-alpha (TNF-α) and transforming growth factor-beta (TGF-β) have been associated with to development of different cancers. Our aim was to investigate the prognostic value of PON1 (rs854560 and rs662), TNF-α...
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