Article
Association between genetic polymorphism of tumor necrosis factor-alpha and risk of oral submucous fibrosis, a pre-cancerous condition of oral cancer.
Journal of dental research - 1 Dec 2001
Chiu C J, Chiang C P, Chang M L, Chen H M, Hahn L J, Hsieh L L, Kuo Y S, Chen C J
Abstract excerpt
Many cytokines have been thought to play important roles in the pathogenesis of oral submucous fibrosis (OSF), an areca nut chewing-specific pre-cancerous condition characterized by the deposition of collagen in oral submucosa. Tumor necrosis factor-alpha (TNF-alpha), situated in the class III region of human leukocyte antigen (HLA), is a mediator with multiple functions, including the regulation of inflammatory...
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