Article
Search for rare protein altering variants influencing susceptibility to multiple myeloma.
Oncotarget - 30 May 2017
Scales Matthew, Chubb Daniel, Dobbins Sara E, Johnson David C, Li Ni, Sternberg Michael J, Weinhold Neils, Stein Caleb, Jackson Graham, Davies Faith E, Walker Brian A, Wardell Christopher P, Houlston Richard S, Morgan Gareth J
Abstract excerpt
The genetic basis underlying the inherited risk of developing multiple myeloma (MM) is largely unknown. To examine the impact of rare protein altering variants on the risk of developing MM we analyzed high-coverage exome sequencing data on 513 MM cases and 1,569 healthy controls, performing both single variant and gene burden tests. We did not identify any recurrent coding low-frequency alleles (1-5%) with...
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