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The ALOXE3 gene variants from patients with Dravet syndrome decrease gene expression and enzyme activity.

Brain research bulletin - 1 May 2021

Gao Mei-Mei, Huang Hao-Ying, Chen Si-Yu, Tang Hui-Ling, He Na, Feng Wen-Cai, Lu Ping, Hu Fei, Yan Hua-Juan, Long Yue-Sheng

Abstract excerpt

Aberrant expression or dysfunction of a number of genes in the brain contributes to epilepsy, a common neurological disorder characterized by recurrent seizures. Local overexpression of arachidonate lipoxygenase 3 (ALOXE3), a key enzyme for arachidonic acid (AA) metabolic pathway, alleviates seizure severities. However, the relationship between the ALOXE3 gene mutation and epilepsy has not been reported until...

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PMID: 33581311
DOI: 10.1016/j.brainresbull.2021.02.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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