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Article

Chronic nickel (II) exposure induces the stemness properties of cancer cells through repressing isocitrate dehydrogenase (IDH1).

Ecotoxicology and environmental safety - 15 Apr 2021

Wang Lingqiao, He Shengnan, Xiong Zhen, Lu Jingxiao, Lin Yuntao, Jin Huidong, Yang Lan

Abstract excerpt

BACKGROUND: Nickel is a component of biomedical alloys that is released during corrosion or friction and causes cytotoxicity, mutation, differentiation or even carcinogenesis in tissues. However, the mechanisms underlying the potential hazards of Nickel-containing alloys implanted in the human body by surgery remain uncertain. OBJECTIVE: To study the effect of Ni(II) (NiCl2•6H2O) on cancer cells. METHODS: A549...

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Identifiers

PMID: 33578097
DOI: 10.1016/j.ecoenv.2021.112031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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