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Article

Cancer Stem-Like Cells Accumulated in Nickel-Induced Malignant Transformation.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Jun 2016

Wang Lei, Fan Jia, Hitron John Andrew, Son Young-Ok, Wise James T F, Roy Ram Vinod, Kim Donghern, Dai Jin, Pratheeshkumar Poyil, Zhang Zhuo, Shi Xianglin

Abstract excerpt

Nickel compounds are known as human carcinogens. Chronic environmental exposure to nickel is a worldwide health concern. Although the mechanisms of nickel-induced carcinogenesis are not well understood, recent studies suggest that stem cells/cancer stem cells are likely important targets. This study examines the role of cancer stem cells in nickel-induced cell transformation. The nontransformed human bronchial...

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Identifiers

PMID: 26962057
DOI: 10.1093/toxsci/kfw044
PMCID: PMC4880134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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