Article
A Metabolomics-Based Approach to Identify Lineage Guiding Molecules in Pericyte Cultures.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021
Alakpa Enateri V, West Christopher C, Goldie Laura, Harper Mhairi M, Burgess Karl, Ulijn Rein V, Dalby Matthew J
Abstract excerpt
We report the use of self-assembled peptide (F2/S) hydrogels and cellular metabolomics to identify a number of innate molecules that are integral to the metabolic processes which drive cellular differentiation of multipotent pericyte stem cells. The culture system relies solely on substrate mechanics to induce differentiation in the absence of traditional differentiation media and therefore is a non-invasive...
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