Article
Improving cartilage phenotype from differentiated pericytes in tunable peptide hydrogels.
Scientific reports - 31 Jul 2017
Alakpa Enateri V, Jayawarna Vineetha, Burgess Karl E V, West Christopher C, Péault Bruno, Ulijn Rein V, Dalby Matthew J
Abstract excerpt
Differentiation of stem cells to chondrocytes in vitro usually results in a heterogeneous phenotype. This is evident in the often detected over expression of type X collagen which, in hyaline cartilage structure is not characteristic of the mid-zone but of the deep-zone ossifying tissue. Methods to better match cartilage developed in vitro to characteristic in vivo features are therefore highly desirable in...
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