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Article

Brain Damage and Gene Expression Across Hereditary Spastic Paraplegia Subtypes.

Movement disorders : official journal of the Movement Disorder Society - 1 Jul 2021

Servelhere Katiane R, Rezende Thiago Junqueira Ribeiro, de Lima Fabrício Diniz, de Brito Mariana Rabelo, de França Nunes Renan Flávio, Casseb Raphael F, Pedroso José Luiz, Barsottini Orlando Graziani P, Cendes Fernando, França Marcondes C

Abstract excerpt

BACKGROUND: Spinal cord has been considered the main target of damage in hereditary spastic paraplegias (HSPs), but mounting evidence indicates that the brain is also affected. Despite this, little is known about the brain signature of HSPs, in particular regarding stratification for specific genetic subtypes. OBJECTIVE: We aimed to characterize cerebral and cerebellar damage in five HSP subtypes (9 SPG3A, 27...

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Identifiers

PMID: 33576112
DOI: 10.1002/mds.28519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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